Acute respiratory compromise in the NICU
- georgschmoelzer
- Mar 10
- 1 min read

Introduction
Acute respiratory compromise (ARC) is a critical and frequent emergency in the Neonatal Intensive Care Unit (NICU). It is characterized by absent, agonal, or inadequate respiration, requiring an immediate response to prevent severe complications. ARC events pose significant risks as they hinder oxygen delivery and carbon dioxide removal, potentially leading to cardiopulmonary arrest.
Etiologies of ARC in Neonates
The primary causes of ARC in neonates can be categorized into:
Upper airway issues – including anatomical abnormalities, airway obstruction, and syndromic disorders.
Lower airway and lung diseases – such as bronchopulmonary dysplasia, pneumonia, and other pulmonary conditions.
Disordered control of breathing – involving neurological or metabolic dysfunctions affecting respiratory drive.
Approximately 1% of NICU admissions experience cardiopulmonary arrest, with ARC being the primary cause in most cases.
Management Strategies
A structured approach is essential in managing ARC, including:
Respiratory support techniques – such as continuous positive airway pressure (CPAP) and positive pressure ventilation (PPV).
Advanced interventions – including extracorporeal membrane oxygenation (ECMO) for severe respiratory distress.
Preventive measures – quality improvement initiatives aimed at reducing incidents like unplanned extubations (UE) and optimizing emergency response strategies.
Multidisciplinary Collaboration in ARC Response
Emergency responses to ARC often require a coordinated effort among neonatologists, respiratory therapists, nurses, and other healthcare professionals. Preparedness, training, and structured emergency protocols are crucial for optimizing outcomes and ensuring timely intervention in neonatal respiratory emergencies.
Conclusion
ARC remains a major challenge in the NICU, demanding prompt recognition and intervention. By understanding its etiologies, implementing evidence-based management strategies, and emphasizing multidisciplinary collaboration, healthcare teams can enhance patient outcomes and reduce the incidence of cardiopulmonary arrest in neonates.
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